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| Kinasera live cell assays for monitoring kinase activity in live cells |
As ARC-Photo probes detect the active form of protein kinases, the assay is suitable for studying the activation mechanisms of protein kinases inside living cells, e. g., determining the potency of GPCR agonists and antagonist as the activity of PKA is modulated by G-protein (Gs and Gi) coupled receptors or direct activation of adenylate cyclases. Moreover, the assay can be exploited for the determination of cell penetrating properties and cellular activity of PKA inhibitors.
Kinasera live cell assays are available in two formats:
For the monitoring of live cells expressing target protein kinases as fusions with fluorescent proteins.
For the monitoring of protein kinase activity in native cell lines.